Neurotrophins: the biological paradox of survival factors eliciting apoptosis
نویسندگان
چکیده
منابع مشابه
Nerve Growth Factors and Neurotrophins
Cell division, cell death, and cell differentiation are hallmarks of embryogenesis. Such processes are supported by neurotrophins that have the capacity of regulating not only developmental processes, but also neuronal survival, morphological adaptation, and neural plasticity. Nerve growth factor (NGF) is a prototype of neurotrophins capable of influencing survival and differentiation of neuron...
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NGF's role in neuronal survival has tended to mask other potential functions. But now the generation of mice lacking both Bax - required for the death of NGF-deprived neurons - and NGF or its receptor has shown that NGF plays a key role in establishing cutaneous innervation and regulating neuropeptide expression.
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It has been reported that phosphoinositide 3-kinase (PI 3-kinase) and its downstream target, protein kinase B (PKB), play a central role in the signaling of cell survival triggered by neurotrophins (NTs). In this report, we have analyzed the involvement of Ca2+ and calmodulin (CaM) in the activation of the PKB induced by NTs. We have found that reduction of intracellular Ca2+ concentration or f...
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PURPOSE Gastric cancer is a biologically heterogeneous disease containing many genetic and epigenetic alterations. In our study, the expression status of apoptosis-inducing p53 and apoptosis-inhibiting Bcl-2 in gastric cancer and their relation with prognosis, if any, was investigated. METHODS Patients that were being followed in our clinic and had histopathologically diagnosed gastric adenoc...
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BACKGROUND Gunshot injuries are the third leading cause of spinal injuries, after falls from a significant height and traffic accidents. Severity of spinal damage from gunshot injury depends upon certain mechanical and biological factors. The aim of the present study was to investigate the effect of biological factors on survival in cases of spinal gunshot injury. METHODS A total of 110 cases...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1998
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400377